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567731 Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

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Tableau de caractéristiques principal

CAS #Empirical Formula
1177741-83-1C₁₅H₁₁ClN₂OS • HCl

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
567731-10MG
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      Description
      OverviewA cell-permeable disubstituted thiazole compound that displays anti-tumor properties. Acts as a potent, substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase (IC50 = 0.5 µM for GST-hSK). Does not affect the kinase activity of hERK2, hPI3K, or PKCα even at concentrations as high as 60 µM. Induces apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC50 = ~ 1-5 µM) through inhibiting sphingosine-1-phosphate production.
      Catalogue Number567731
      Brand Family Calbiochem®
      Synonyms2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I
      References
      ReferencesFrench, K.J., et al. 2003. Cancer Res. 63, 5962.
      Product Information
      CAS number1177741-83-1
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₅H₁₁ClN₂OS • HCl
      Chemical formulaC₁₅H₁₁ClN₂OS • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetGST-hsk
      Primary Target IC<sub>50</sub>0.5 µM for GST-hSK
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      567731-10MG 07790788051686