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QIA117 Senescence Detection Kit

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QIA117
  
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      Aperçu

      Tableau de caractéristiques principal

      Detection Methods
      Colorimetric
      Description
      OverviewUseful for the histochemical detection of senescent cells. The failure of cells to become senescent may lead to tumor progression. Higher levels of β-Galactosidase is considered as a good marker for senescent cells. The mechanism of this is believed to be due to the increased lysosomal content of senescent cells, resulting in an increase of the lysosomal enzyme β-galactosidase. Cells can be observed using microscope.
      Catalogue NumberQIA117
      Brand Family Calbiochem®
      Materials Required but Not Delivered PBS
      DMF
      References
      ReferencesKurz, D.J., et al. 2000. J. Cell Sci. 113, 3613.
      Dimri, G.P., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 9363.
      Product Information
      Detection methodColorimetric
      Form250 Tests
      Format12-well plate
      Kit containsFixative Solution, X-Gal, Staining Solution, Staining Supplement, and a user protocol.
      Quality LevelMQ100
      Applications
      Application ReferencesFunasaka, T., et al. 2007. J. Biol. Chem. 282, 36362. Chen, Z., et al. 2005. Nature 436, 725.
      Biological Information
      Assay time30 min. plus overnight incubation
      Sample TypeIntact cells
      Product Usage Statements
      Intended useThe Calbiochem® Senescence Detection Kit is useful for the histochemical detection of senescent cells. The failure of cells to become senescent may lead to tumor progression. The mechanism of this is believed to be the increased lysosomal content of senescent cells resulting in an increase of the lysosomal enzyme β-galactosidase.
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Multiple Toxicity Values, refer to MSDS
      Storage -20°C
      Storage ConditionsUpon arrival store the entire contents of the kit at -20°C.
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Supplemental Information
      Kit containsFixative Solution, X-Gal, Staining Solution, Staining Supplement, and a user protocol.
      Global Trade Item Number
      Référence GTIN
      QIA117 0