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573127 STAT3 Inhibitor XII, SPI - Calbiochem

The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

STAT3 Inhibitor XII, SPI - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: H₂N-FISKERERAILSTKPPGTFLLRFSESSK-CO₂H

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573127
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₄₆H₂₃₈N₄₀O₄₂

Prix & Disponibilité

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573127-5MG
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      Description
      OverviewA cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.
      Catalogue Number573127
      Brand Family Calbiochem®
      SynonymsH₂N-FISKERERAILSTKPPGTFLLRFSESSK-CO₂H
      References
      ReferencesZhao, W., et al. 2010. J. Biol. Chem. 285, 35855.
      Product Information
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₄₆H₂₃₈N₄₀O₄₂
      Chemical formulaC₁₄₆H₂₃₈N₄₀O₄₂
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Peptide SequenceH-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Tyr-Lys-Pro-Pro-Gly-Tyr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      573127-5MG 04055977266085

      Documentation

      STAT3 Inhibitor XII, SPI - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      STAT3 Inhibitor XII, SPI - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      573127

      Références bibliographiques

      Aperçu de la référence bibliographique
      Zhao, W., et al. 2010. J. Biol. Chem. 285, 35855.

      Informations techniques

      Titre
      JAK/STAT Signaling Research Focus
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2012 JSW
      SynonymsH₂N-FISKERERAILSTKPPGTFLLRFSESSK-CO₂H
      DescriptionA cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄₆H₂₃₈N₄₀O₄₂
      Peptide SequenceH-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Tyr-Lys-Pro-Pro-Gly-Tyr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) for H₂O (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhao, W., et al. 2010. J. Biol. Chem. 285, 35855.