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573096 STAT3 Inhibitor Peptide, Cell-Permeable

STAT3 Inhibitor Peptide, Cell-Permeable, is an analog of Stat3-SH2 domain-binding phosphopeptide with a C-terminal membrane translocating sequence. A selective, potent blocker of Stat3 activation.

STAT3 Inhibitor Peptide, Cell-Permeable : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: PpYLKTK-mts, STAT3 Inhibitor IV

Primary Target: Blocker of Stat3 activation
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573096
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₉₂H₁₅₇N₂₀O₂₄P

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
573096-1MG
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Disponible en quantités limitées
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      		 Ampoule plast. 1 mg
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      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
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      573096-5MG
      Récupération des données relatives à la disponibilité...
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      Disponibilité limitée Disponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          		 Ampoule plast. 5 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          Maximum Quantity is
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
          —
          Demander le prix
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          Description
          OverviewA cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.
          Supplied as a trifluoroacetate salt.
          Catalogue Number573096
          Brand Family Calbiochem®
          SynonymsPpYLKTK-mts, STAT3 Inhibitor IV
          References
          ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₂H₁₅₇N₂₀O₂₄P
          Chemical formulaC₉₂H₁₅₇N₂₀O₂₄P
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationSTAT3 Inhibitor Peptide, Cell-Permeable, is an analog of Stat3-SH2 domain-binding phosphopeptide with a C-terminal membrane translocating sequence. A selective, potent blocker of Stat3 activation.
          Biological Information
          Primary TargetBlocker of Stat3 activation
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Référence GTIN
          573096-1MG 07790788051730
          573096-5MG 07790788051747

          Documentation

          STAT3 Inhibitor Peptide, Cell-Permeable FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          STAT3 Inhibitor Peptide, Cell-Permeable Certificats d'analyse

          TitreNuméro de lot
          573096

          Références bibliographiques

          Aperçu de la référence bibliographique
          Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.

          Brochure

          Titre
          An Introduction to Inhibitors and Their Biological Applications - 1st Edition

          Informations techniques

          Titre
          JAK/STAT Signaling Research Focus

          Citations

          Titre
        • Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
        • Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
        • Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
          		•
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          SynonymsPpYLKTK-mts, STAT3 Inhibitor IV
          DescriptionA cell-permeable analog of the Stat3-SH2 domain-binding phospho-peptide (Cat. No. 573095) that contains a C-terminal membrane translocating sequence (MTS) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat3-dependent Src transformation with no effect on Stat3-independent Ras transformation.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₂H₁₅₇N₂₀O₂₄P
          Peptide SequenceH-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.
          Citation
        • Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
        • Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
        • Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
          		•