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559410 SB 290157 - CAS 1140525-25-2 - Calbiochem

SB 290157, CAS 1140525-25-2, is a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic GPCRs.

SB 290157 - CAS 1140525-25-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA

Primary Target: C3a receptor
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559410
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Tableau de caractéristiques principal

CAS #Empirical Formula
1140525-25-2C₂₂H₂₈N₄O₄ · CF₃CO₂H

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      Description
      OverviewA non-peptide that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic G-protein-coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from Guinea pig platelets (IC50 = 30 nM). Exhibits anti-inflammatory properties. Supplied as a trifluoroacetate salt.
      Catalogue Number559410
      Brand Family Calbiochem®
      SynonymsN²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA
      References
      ReferencesAmes, R.S., et al. 2001. J. Immunol. 166, 6341.
      Product Information
      CAS number1140525-25-2
      ATP CompetitiveN
      FormLyophilized
      Hill FormulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
      Chemical formulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationSB 290157, CAS 1140525-25-2, is a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (IC50 = 200 nM). Does not antagonize C5aR or other chemotactic GPCRs.
      Biological Information
      Primary TargetC3a receptor
      Primary Target IC<sub>50</sub>200 nM against the anaphylatoxin C3a receptor; 7, 12.5, and 27.7 nM, in blocking C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Do not reuse solutions diluted in physiological buffers.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      559410-10MG 04055977268140

      Documentation

      SB 290157 - CAS 1140525-25-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      SB 290157 - CAS 1140525-25-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      559410

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ames, R.S., et al. 2001. J. Immunol. 166, 6341.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      SynonymsN²-[(2,2-Diphenylethoxy)acetyl]-L-arginine, TFA
      DescriptionA non-peptide with anti-inflammatory properties that acts as a selective, high affinity, competitive antagonist of the anaphylatoxin C3a receptor (C3aR; IC50 = 200 nM). Does not antagonize C5aR or other chemotactic G-protein coupled receptors. Blocks C3a-induced internalization of C3aR in human neutrophils and C3a-induced Ca2+ mobilization in basophilic leukemia RBL-2H3 cells expressing murine, guinea pig, or human C3aR (IC50 = 7, 12.5, and 27.7 nM, respectively). Also blocks C3a-mediated ATP release from guinea pig platelets (IC50 = 30 nM).
      FormLyophilized
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1140525-25-2
      Chemical formulaC₂₂H₂₈N₄O₄ · CF₃CO₂H
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Do not reuse solutions diluted in physiological buffers.
      Toxicity Standard Handling
      ReferencesAmes, R.S., et al. 2001. J. Immunol. 166, 6341.