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466220 S-Methylisothiourea, Sulfate

A highly selective, cell-permeable inhibitor of inducible nitric oxide synthase (iNOS).

S-Methylisothiourea, Sulfate : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-Methyl-2-thiopseudourea, Sulfate, SMT

Primary Target: iNOS
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      867-44-7(C₂H₆N₂S)₂ · H₂SO₄
      Description
      Overview

      This product has been discontinued.




      A highly selective, cell-permeable inhibitor of inducible nitric oxide synthase (iNOS). Reported to be 10 to 30-fold more potent than L-NMMA (Cat. No. 475886) as an inhibitor of iNOS in immunostimulated cultured macrophages (EC50 = 6 µM) and vascular smooth muscle cells (EC50 = 2 µM).
      Catalogue Number466220
      Brand Family Calbiochem®
      Synonyms2-Methyl-2-thiopseudourea, Sulfate, SMT
      References
      ReferencesSouthan, G.J., et al. 1995. Br. J. Pharmacol. 114, 510.
      Szabó, C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12472.
      Product Information
      CAS number867-44-7
      ATP CompetitiveN
      FormWhite crystals
      Hill Formula(C₂H₆N₂S)₂ · H₂SO₄
      Chemical formula(C₂H₆N₂S)₂ · H₂SO₄
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetiNOS
      Primary Target IC<sub>50</sub>EC50 = 6 µM against iNOS in immunostimulated cultured macrophages; EC50 = 2 µM against iNOS in vascular smooth muscle cells
      Purity≥99% by elemental analysis
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUM9200000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      466220 0

      Documentation

      S-Methylisothiourea, Sulfate Certificats d'analyse

      TitreNuméro de lot
      466220

      Références bibliographiques

      Aperçu de la référence bibliographique
      Southan, G.J., et al. 1995. Br. J. Pharmacol. 114, 510.
      Szabó, C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12472.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2008 RFH
      Synonyms2-Methyl-2-thiopseudourea, Sulfate, SMT
      DescriptionA cell-permeable, highly selective inhibitor of inducible nitric oxide synthase (iNOS). Reported to be 10-30 fold more potent than L-NMMA (Cat. No. 475886) as an inhibitor of iNOS in immunostimulated cultured macrophages (EC50 = 6 µM) and vascular smooth muscle cells (EC50 = 2 µM).
      FormWhite crystals
      CAS number867-44-7
      RTECSUM9200000
      Chemical formula(C₂H₆N₂S)₂ · H₂SO₄
      Structure formulaStructure formula
      Purity≥99% by elemental analysis
      SolubilityH₂O
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Standard Handling
      ReferencesSouthan, G.J., et al. 1995. Br. J. Pharmacol. 114, 510.
      Szabó, C., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 12472.