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14-479M Rsk1/MAPKAP Kinase 1a Protein, active, Rat, 250 µg

Active, recombinant full-length rat RSK1 (residues 1-end), containing additional N-terminal His6 & HA (YPYDV PDYA) tags, for use in Kinase Assays.

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14-479M
250 µg  Also available in 10 μg size (cat#14-479) and in bulk (cat# 14-479-K).
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      Replacement Information
      Description
      Catalogue Number14-479M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionRsk1/MAPKAP Kinase 1a Protein, active, Rat, 250 µg
      OverviewRecombinant full-length rat RSK1 (residues 1-end), containing additional Nterminal His6 and HA (YPYDV PDYA) tags
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, recombinant full-length rat RSK1 (residues 1-end), containing additional N-terminal His6 & HA (YPYDV PDYA) tags, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed in baculovirus in Sf21 cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
      Gene Symbol
      • RPS6KA1
      • HU-1
      • RSK-1
      • MAPKAPK1A
      • RSK
      • pp90RSK1
      • p90S6K
      • RSK1
      Protein TargetRsk1
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyAGC
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q15418 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
      COFACTOR: Magnesium.
      SIZE: 735 amino acids; 82723 Da
      SUBUNIT: Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.
      PTM: Autophosphorylated on Ser-380, as part of the activation process.
      SIMILARITY: SwissProt: Q15418 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 2 protein kinase domains.
      Molecular Weight88kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of the MAPKAP Kinase 2 substrate peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -70C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-479) and in bulk (cat# 14-479-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-479M 04053252512407