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554325 Resveratrol - CAS 501-36-0 - Calbiochem

A phenolic product found in both grape skins and wines.

Resveratrol - CAS 501-36-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: trans-3,4ʹ,5-Trihydroxystilbene

Primary Target: COX-1
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554325
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Tableau de caractéristiques principal

CAS #Empirical Formula
501-36-0C₁₄H₁₂O₃

Prix & Disponibilité

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554325-25MG
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      		 Ampoule plast. 25 mg
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      Description
      OverviewA phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      Catalogue Number554325
      Brand Family Calbiochem®
      Synonymstrans-3,4ʹ,5-Trihydroxystilbene
      References
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Lin, H.Y., et al. 2002. J. Urol. 168, 748.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
      Jang, M., et al. 1997. Science 275, 218.
      Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
      Product Information
      CAS number501-36-0
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₄H₁₂O₃
      Chemical formulaC₁₄H₁₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-1
      Primary Target IC<sub>50</sub>ED50 = 15 µM against COX-1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      554325-25MG 04055977193053

      Documentation

      Resveratrol - CAS 501-36-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Resveratrol - CAS 501-36-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      554325

      Références bibliographiques

      Aperçu de la référence bibliographique
      Howitz, K.T., et al. 2003. Nature 425, 191.
      Lin, H.Y., et al. 2002. J. Urol. 168, 748.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
      Jang, M., et al. 1997. Science 275, 218.
      Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonymstrans-3,4ʹ,5-Trihydroxystilbene
      DescriptionA phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 µM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 µM). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 µM) and acts as an anti-mutagenic agent (ED50 = 15 µM) in TM677 cells treated with DMBA. Also selectively inhibits P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.
      FormOff-white solid
      CAS number501-36-0
      Chemical formulaC₁₄H₁₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 8158
      ReferencesHowitz, K.T., et al. 2003. Nature 425, 191.
      Lin, H.Y., et al. 2002. J. Urol. 168, 748.
      Klabunde, T., et al. 2000. Nat. Struct. Biol. 7, 312.
      Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262, 20.
      Jang, M., et al. 1997. Science 275, 218.
      Chen, C.K., et al. 1996. Gen. Pharmacol. 27, 363.