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540215 PTP CD45 Inhibitor - CAS 345630-40-2 - Calbiochem

The PTP CD45 Inhibitor, also referenced under CAS 345630-40-2, controls the biological activity of PTP CD45. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

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Synonymes: N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V

Primary Target: CD45 using pNPP as a substrate
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540215
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Tableau de caractéristiques principal

CAS #Empirical Formula
345630-40-2C₁₉H₁₇NO₃

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540215-5MG
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      Description
      OverviewA cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45 (IC50 = 200 nM or 3.8 µM using pNPP or phosphorylated Ick505 peptide as a substrate, respectively). Does not effectively inhibit PTPIB (IC50 >30 µM using phosphorylated Ick505 peptide as a substrate). The phenanthrenedione group does not function as a thiol oxidizing agent. One of the most potent inhibitor of phosphatase tensin homolog deleted on chromosome 10 (PTEN) that enhances PIP3 signaling in a variety of cells and improves the efficacy of granulocyte transfusion in murine models of neutropenia-related pneumonia.
      Catalogue Number540215
      Brand Family Calbiochem®
      SynonymsN-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethyl-propionamide, PTPase CD45 Inhibitor, Protein Tyrosine Phosphatase CD45 Inhibitor, SF1670, PTP Inhibitor XIX, PTP1B Inhibitor VI, PTPN2/TCPTP Inhibitor, SHP1 Inhibitor VII, YPTP1 Inhibitor, YOP Inhibitor, PTEN Inhibitor V
      References
      ReferencesLi, Y., et al. 2011. Blood 117, 6702.
      Urbanek, R.A., et al. 2001. J. Med. Chem. 44, 1777.
      Product Information
      CAS number345630-40-2
      ATP CompetitiveN
      FormRed-violet solid
      Hill FormulaC₁₉H₁₇NO₃
      Chemical formulaC₁₉H₁₇NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCD45 using pNPP as a substrate
      Primary Target IC<sub>50</sub>200 nM or 3.8 µM against CD45 using pNPP or phosphorylated Ick505 peptide as a substrate, respectively
      Purity≥ 97% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      540215-5MG 07790788051372