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14-335M PRAK Protein, unactive, 250 µg

Unactive, recombinant full-length human PRAK with an N-terminal His-tag, for use in Kinase Assays.

14-335M
250 µg  Also available in 50 mg size (cat#14-335)
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      Replacement Information
      Description
      Catalogue Number14-335M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPRAK Protein, unactive, 250 µg
      OverviewRecombinant full-length human PRAK with an N-terminal His-tag
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationUnactive, recombinant full-length human PRAK with an N-terminal His-tag, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in Sf9 cells
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
      Gene Symbol
      • MAPKAPK5
      • PRAK
      Protein TargetPRAK
      Purification MethodNi-NTA agarose
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8IW41 # Mediates stress-induced small heat shock protein 27 phosphorylation.
      SIZE: 473 amino acids; 54220 Da
      SUBUNIT: Interacts with SQSTM1.
      SUBCELLULAR LOCATION: Cytoplasm (Probable). Nucleus. Note=Also observed in the nucleus.
      TISSUE SPECIFICITY: Expressed ubiquitously.
      PTM: Phosphorylated on Thr-182; which is the regulatory phosphorylation site and is located on the T-loop/loop 12.
      SIMILARITY: SwissProt: Q8IW41 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
      Molecular Weight54kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of PRAK Substrate Peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 6 months at -20C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 50 mg size (cat#14-335)
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-335M 04053252924156

      Documentation

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      14-335 PRAK Protein, unactive, 50 µg Prix & Disponibilité

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      Catégories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases