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539510 PP2A₂, Bovine Kidney

PP2A₂, Bovine Kidney : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Protein Phosphatase 2A₂

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      Aperçu

      Replacement Information
      Description
      OverviewNative, PP2A2 from bovine kidney. A divalent cation-independent protein serine/threonine phosphatase involved in the control of numerous cellular processes. Has a catalytic subunit of 36 kDa and a regulatory subunit of 60 kDa. Transient phosphorylation of the catalytic subunit on threonine or tyrosine residues has been reported to inactivate PP2A2. Inhibits nuclear telomerase activity in human breast cancer cells.

      This product has been discontinued.
      Catalogue Number539510
      Brand Family Calbiochem®
      SynonymsProtein Phosphatase 2A₂
      References
      ReferencesLi, H., et al. 1997. J. Biol. Chem. 272, 16729.
      Guo, H. and Damuni, Z. 1993. Proc. Natl. Acad. Sci. USA 90, 2500.
      Hendrix, P., et al. 1993. J. Biol. Chem. 268, 15267.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Chen, J., et al. 1992. Science 257, 1261.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      Damuni, Z., et al. 1989. J. Biol. Chem. 264, 6412.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will release 1.0 nmol of [³²P]P<sub>i</sub> from ³²P-labeled phosphorylase per min at 30°C, pH 7.0.
      EC number3.1.3.16
      FormLiquid
      FormulationIn 25 mM Tris-HCl, 14 mM βME, 1 mM benzamidine, 100 µM EDTA, 100 µM PMSF, 50% glycerol, pH 7.0.
      Applications
      Biological Information
      Purity≥90% by SDS-PAGE
      Specific Activity≥750 units/mg
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      539510 0

      Documentation

      PP2A₂, Bovine Kidney Certificats d'analyse

      TitreNuméro de lot
      539510

      Références bibliographiques

      Aperçu de la référence bibliographique
      Li, H., et al. 1997. J. Biol. Chem. 272, 16729.
      Guo, H. and Damuni, Z. 1993. Proc. Natl. Acad. Sci. USA 90, 2500.
      Hendrix, P., et al. 1993. J. Biol. Chem. 268, 15267.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Chen, J., et al. 1992. Science 257, 1261.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      Damuni, Z., et al. 1989. J. Biol. Chem. 264, 6412.

      Brochure

      Titre
      Protein Phosphatases Technical Bulletin
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-September-2008 RFH
      SynonymsProtein Phosphatase 2A₂
      DescriptionNative, PP2A2 from bovine kidney. A divalent cation-independent protein serine/threonine phosphatase involved in the control of numerous cellular processes. Has a catalytic subunit of 36 kDa and a regulatory subunit of 60 kDa. Transient phosphorylation of the catalytic subunit on threonine or tyrosine residues has been reported to inactivate PP2A2. Inhibits nuclear telomerase activity in human breast cancer cells.
      FormLiquid
      FormulationIn 25 mM Tris-HCl, 14 mM βME, 1 mM benzamidine, 100 µM EDTA, 100 µM PMSF, 50% glycerol, pH 7.0.
      EC number3.1.3.16
      Purity≥90% by SDS-PAGE
      Specific activity≥750 units/mg
      Unit definitionOne unit is defined as the amount of enzyme that will release 1.0 nmol of [³²P]Pi from ³²P-labeled phosphorylase per min at 30°C, pH 7.0.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesLi, H., et al. 1997. J. Biol. Chem. 272, 16729.
      Guo, H. and Damuni, Z. 1993. Proc. Natl. Acad. Sci. USA 90, 2500.
      Hendrix, P., et al. 1993. J. Biol. Chem. 268, 15267.
      Amick, G.D., et al. 1992. Biochem. J. 287, 1019.
      Chen, J., et al. 1992. Science 257, 1261.
      Cohen, P., et al. 1990. Trends Biochem. Sci. 15, 98.
      Damuni, Z., et al. 1989. J. Biol. Chem. 264, 6412.