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527450 PKR Inhibitor - CAS 608512-97-6 - Calbiochem

PKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.

PKR Inhibitor - CAS 608512-97-6 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: PKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I

Primary Target: PKR
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527450
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Tableau de caractéristiques principal

CAS #Empirical Formula
608512-97-6C₁₃H₈N₄OS

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527450-5MG
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      Description
      OverviewAn imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC50 = 210 nM) and rescue PKR-dependent translation block (IC50 = 100 nM). Inactive control is also available (Cat. No. 527455). Shown to increase the late phase of long-lasting synaptic potentiation, and enhance long-term memory in mice. Also available as a 50 mM solution in DMSO (Cat. No. 527451).
      Catalogue Number527450
      Brand Family Calbiochem®
      SynonymsPKRi, Double-stranded RNA-dependent Protein Kinase Inhibitor, C16, Double-stranded RNA-activated Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I
      References
      ReferencesZhu, P.J., et al. 2011. Cell 147, 1384.
      Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308, 50.
      Product Information
      CAS number608512-97-6
      ATP CompetitiveN
      FormOrange to orange brown solid
      Hill FormulaC₁₃H₈N₄OS
      Chemical formulaC₁₃H₈N₄OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPKR Inhibitor, CAS 608512-97-6, is a potent, ATP-binding site directed PKR inhibitor that blocks RNA-induced PKR autophosphorylation (IC50 = 210 nM). Rescue PKR-dependent translation block.
      Biological Information
      Primary TargetPKR
      Primary Target IC<sub>50</sub>210 nM inhibiting RNA-induced PKR autophosphorylation and 100 nM in rescuing PKR-dependent translation block
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      527450-5MG 07790788055615