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528120 PIPER - CAS 213416-70-7 - Calbiochem

A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA.

PIPER - CAS 213416-70-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV

Primary Target: human telomerase
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      213416-70-7C₃₈H₃₆N₄O₄
      Description
      Overview

      This product has been discontinued.



      A perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3′-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May also be useful as an antiproliferative agent.
      Catalogue Number528120
      Brand Family Calbiochem®
      SynonymsN,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV
      References
      ReferencesHan, H., et al. 1999. Biochemistry 38, 6981.
      Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.
      Product Information
      CAS number213416-70-7
      ATP CompetitiveN
      FormDark purple solid
      Hill FormulaC₃₈H₃₆N₄O₄
      Chemical formulaC₃₈H₃₆N₄O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targethuman telomerase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22-40-68

      Harmful by inhalation, in contact with skin and if swallowed.
      Limited evidence of a carcinogenic effect.
      Possible risks of irreversible effects.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      528120 0

      Documentation

      PIPER - CAS 213416-70-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PIPER - CAS 213416-70-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      528120

      Références bibliographiques

      Aperçu de la référence bibliographique
      Han, H., et al. 1999. Biochemistry 38, 6981.
      Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      SynonymsN,Nʹ-bis[2-(1-Piperidino)ethyl]-3,4,9,10-perylenetetracarboxylic Diimide, Telomerase Inhibitor IV
      DescriptionA perylene-based ligand that potently inhibits human telomerase by binding to G-quadruplex DNA. The strongest binding site for PIPER appears to be the 3'-boundary of the G-quadruplex. Can also bind non-specifically to nucleic acids. May be useful as an antiproliferative agent.
      FormDark purple solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number213416-70-7
      Chemical formulaC₃₈H₃₆N₄O₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Solubility5% Acetic acid (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesHan, H., et al. 1999. Biochemistry 38, 6981.
      Fedoroff, O.Y., et al. 1998. Biochemistry 37, 12367.