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513033 PD 168393 - CAS 194423-15-9 - Calbiochem

PD 168393, CAS 194423-15-9, is a cell-permeable, potent, selective, irreversible, ATP-competitive inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM).

PD 168393 - CAS 194423-15-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline

Primary Target: EGFR
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513033
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Tableau de caractéristiques principal

CAS #Empirical Formula
194423-15-9C₁₇H₁₃BrN₄O

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      Description
      OverviewA potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
      Catalogue Number513033
      Brand Family Calbiochem®
      Synonyms4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
      References
      ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.
      Product Information
      CAS number194423-15-9
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₇H₁₃BrN₄O
      Chemical formulaC₁₇H₁₃BrN₄O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPD 168393, CAS 194423-15-9, is a cell-permeable, potent, selective, irreversible, ATP-competitive inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM).
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>700 pM against EGFR
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      513033-1MG 04055977198638

      Documentation

      PD 168393 - CAS 194423-15-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PD 168393 - CAS 194423-15-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      513033

      Références bibliographiques

      Aperçu de la référence bibliographique
      Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.

      Posters

      Titre
      Human Kinome & InhibitorSelect™ Libraries
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2015 JSW
      Synonyms4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
      DescriptionA potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 0.70 nM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number194423-15-9
      Chemical formulaC₁₇H₁₃BrN₄O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesFry, D.W., et al. 1998. Proc. Natl. Acad. Sci USA 95, 12022.