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300270 PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem

The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline

Primary Target: PARP
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300270
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
129075-73-6C₁₈H₂₆N₂O₂

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300270-1MG
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      Description
      OverviewA potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
      Catalogue Number300270
      Brand Family Calbiochem®
      Synonyms3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
      References
      ReferencesEliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
      Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
      Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.
      Product Information
      CAS number129075-73-6
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₈H₂₆N₂O₂
      Chemical formulaC₁₈H₂₆N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPARP
      Primary Target IC<sub>50</sub>40 nM
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      300270-1MG 04055977198010

      Documentation

      PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      300270

      Références bibliographiques

      Aperçu de la référence bibliographique
      Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
      Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
      Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-June-2008 RFH
      Synonyms3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
      DescriptionA very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC50 = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.
      FormOff-white solid
      CAS number129075-73-6
      Chemical formulaC₁₈H₂₆N₂O₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Harmful
      ReferencesEliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
      Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
      Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.