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506274 PACOCF₃ - CAS 141022-99-3 - Calbiochem

A novel Ca2+-independent and reversible inhibitor of phospholipase A₂ (PLA₂; IC₅₀ = 3.8 µM).

PACOCF₃ - CAS 141022-99-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Palmitoyl Trifluoromethyl Ketone

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506274
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Tableau de caractéristiques principal

CAS #Empirical Formula
141022-99-3C₁₇H₃₁F₃O

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506274-5MG
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      Description
      OverviewA novel Ca2+-independent and reversible inhibitor of phospholipase A2 (PLA2; IC50 = 3.8 µM). May also inhibit Ca2+-dependent PLA2 at much higher concentrations (IC50 = 45 µM).
      Catalogue Number506274
      Brand Family Calbiochem®
      SynonymsPalmitoyl Trifluoromethyl Ketone
      References
      ReferencesConde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
      Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
      Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
      Product Information
      CAS number141022-99-3
      ATP CompetitiveN
      FormLiquid
      FormulationIn ethanol.
      Hill FormulaC₁₇H₃₁F₃O
      Chemical formulaC₁₇H₃₁F₃O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPLA₂
      Primary Target IC<sub>50</sub>3.8 µM and 45 µM against phospholipase A2 (PLA2) and Ca2+-dependent PLA2, respectively.
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      506274-5MG 04055977272437

      Documentation

      PACOCF₃ - CAS 141022-99-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      PACOCF₃ - CAS 141022-99-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      506274

      Références bibliographiques

      Aperçu de la référence bibliographique
      Conde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
      Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
      Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-April-2011 RFH
      SynonymsPalmitoyl Trifluoromethyl Ketone
      DescriptionA novel Ca2+-independent phospholipase A2 inhibitor (IC50 = 3.8 µM). May also inhibit Ca2+-dependent phospholipase A2 at higher concentrations (IC50 = 45 µM)
      FormLiquid
      FormulationIn ethanol.
      CAS number141022-99-3
      Chemical formulaC₁₇H₃₁F₃O
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilitySupplied as a solution in ethanol. To change the solvent, evaporate the ethanol with a stream of nitrogen and immediately reconstitute with the solvent of choice. Soluble in DMSO (30 mg/ml). Only minimally soluble in aqueous buffers; do not use basic buffers; unstable at basic pH.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Product has a very low melting point. The product will change from a solid to a liquid if held in your hand or kept at room temperature or warmer for any period of time. It is best to keep the product cool while in use by placing it in the refrigerator or on ice during experimentation. Once diluted in buffer, do not store in aqueous solutions for >1 day.
      Toxicity Standard Handling
      ReferencesConde-Frieboes, K., et al. 1996. J. Am. Chem. Soc. 118, 5519.
      Lio, Y.C., et al. 1996. Biochim. Biophys. Acta 1302, 55.
      Ackermann, E.J., et al. 1995. J. Biol. Chem. 270, 445.