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496100 Omeprazole - CAS 73590-58-6 - Calbiochem

A cell-permeable pyridyl methylsulfinyl benzimidazole compound that acts as selective proton pump inhibitor.

Omeprazole - CAS 73590-58-6 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: H 168/68, 5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole

Primary Target: proton pump
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496100
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
73590-58-6C₁₇H₁₉N₃O₃S

Prix & Disponibilité

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496100-50MG
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      		 Ampoule plast. 50 mg
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      Description
      OverviewA cell-permeable pyridyl methylsulfinyl benzimidazole compound that acts as selective proton pump inhibitor. Behaves as a prodrug by undergoing an acid-catalyzed rearrangement to a thiol-reactive cationic sulfenamide that inhibits (H+, K+)-ATPase in the gastric milieu. An aryl hydrocarbon-like inducer of cytochrome P450 secretion in human liver.
      Catalogue Number496100
      Brand Family Calbiochem®
      SynonymsH 168/68, 5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
      References
      ReferencesLambrecht, N., et al. 2000. J. Biol. Chem. 275, 4041.
      Besancon, M., et al. 1997. J. Biol. Chem. 272, 22438.
      Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol. 35, 277.
      Diaz, D., et al. 1990. Gastroenterology 99, 737.
      Fellenius, E., et al. 1981. Nature 290, 159.
      Product Information
      CAS number73590-58-6
      ATP CompetitiveN
      FormTan to off-white solid
      Hill FormulaC₁₇H₁₉N₃O₃S
      Chemical formulaC₁₇H₁₉N₃O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetproton pump
      Purity≥94% by HPLC
      Physicochemical Information
      Cell permeableY
      ContaminantsHeavy metals: ≤20 ppm
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDD9087000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      496100-50MG 04055977199833

      Documentation

      Omeprazole - CAS 73590-58-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Omeprazole - CAS 73590-58-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      496100

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lambrecht, N., et al. 2000. J. Biol. Chem. 275, 4041.
      Besancon, M., et al. 1997. J. Biol. Chem. 272, 22438.
      Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol. 35, 277.
      Diaz, D., et al. 1990. Gastroenterology 99, 737.
      Fellenius, E., et al. 1981. Nature 290, 159.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-March-2013 JSW
      SynonymsH 168/68, 5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
      DescriptionA cell-permeable, selective proton pump inhibitor. Behaves as a prodrug by undergoing an acid-catalyzed rearrangement to a thiol-reactive cationic sulfenamide that inhibits (H+-K+)-ATPase in the gastric milieu. Also acts as an aryl hydrocarbon-like inducer of cytochrome P450 secretion in human liver.
      FormTan to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number73590-58-6
      RTECSDD9087000
      Chemical formulaC₁₇H₁₉N₃O₃S
      Structure formulaStructure formula
      Purity≥94% by HPLC
      ContaminantsHeavy metals: ≤20 ppm
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 6845
      ReferencesLambrecht, N., et al. 2000. J. Biol. Chem. 275, 4041.
      Besancon, M., et al. 1997. J. Biol. Chem. 272, 22438.
      Sachs, G., et al. 1995. Ann. Rev. Pharmacol. Toxicol. 35, 277.
      Diaz, D., et al. 1990. Gastroenterology 99, 737.
      Fellenius, E., et al. 1981. Nature 290, 159.