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481984 Nifuroxazide - CAS 965-52-6 - Calbiochem

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity.

Nifuroxazide - CAS 965-52-6 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone

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481984
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Aperçu

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Tableau de caractéristiques principal

CAS #Empirical Formula
965-52-6C₁₂H₉N₃O₅

Prix & Disponibilité

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481984-500MG
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      		 Ampoule plast. 500 mg
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      Description
      OverviewA cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.
      Catalogue Number481984
      Brand Family Calbiochem®
      Synonyms5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
      References
      ReferencesNelson, E.A., et al. 2008. Blood 112, 5095.
      Product Information
      CAS number965-52-6
      FormBright yellow solid
      Hill FormulaC₁₂H₉N₃O₅
      Chemical formulaC₁₂H₉N₃O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      481984-500MG 04055977183450

      Documentation

      Nifuroxazide - CAS 965-52-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Nifuroxazide - CAS 965-52-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      481984

      Références bibliographiques

      Aperçu de la référence bibliographique
      Nelson, E.A., et al. 2008. Blood 112, 5095.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2009 RFH
      Synonyms5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
      DescriptionA cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.
      FormBright yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number965-52-6
      Chemical formulaC₁₂H₉N₃O₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesNelson, E.A., et al. 2008. Blood 112, 5095.