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508148 Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone

Primary Target: 5-HT2A
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508148
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
82752-99-6C₂₅H₃₂ClN₅O2·HCl

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      Description
      OverviewA potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
      Catalogue Number508148
      Brand Family Calbiochem®
      Synonyms5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
      References
      ReferencesKim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
      Cusack, B. et al. 1994. Psychopharmacol. 114, 559.
      Product Information
      CAS number82752-99-6
      FormWhite solid
      Hill FormulaC₂₅H₃₂ClN₅O2·HCl
      Chemical formulaC₂₅H₃₂ClN₅O2·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT2A
      Primary Target K<sub>i</sub>26nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.08148.0001 04055977242867

      Documentation

      Nefazodone Hydrochloride - CAS 82752-99-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
      Cusack, B. et al. 1994. Psychopharmacol. 114, 559.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      Synonyms5-HT2A Serotonin Receptor Antagonist, Nefazodone, BMY-13754, MJ-13754-1, Serzone
      DescriptionA potent 5-HT2A receptor antagonist (Kd = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (Kd = 48 nM) and 5-HT1A receptor (Kd = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.
      FormWhite solid
      CAS number82752-99-6
      Chemical formulaC₂₅H₃₂ClN₅O2·HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (25 mM) or Ethanol (10 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, J.-A. et al. 2012. Toxicol. Lett. 214, 175.
      Cusack, B. et al. 1994. Psychopharmacol. 114, 559.