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567500 Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem

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Synonymes: (4-Cyanobenzo[b]thiophene-2-carbonyl)guanidine, methanesulfonate, NHE-1 Inhibitor

Primary Target: Inhibits NHE-1-meidated pH recovery after acidosis
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      861218-38-4C₁₁H₈N₄OS • CH₃SO₃H
      Description
      Overview

      This product has been discontinued.



      A cell-permeable acylguanidine compound that inhibits NHE-1-meidated pH recovery after acidosis in PS120 cells (IC50 = 2.0 µM). Shown exhibit cardioprotective efficacy both in an isolated rat heart ischemia model in vitro and in a rat myocardial infarction model in vivo.
      Catalogue Number567500
      Brand Family Calbiochem®
      Synonyms(4-Cyanobenzo[b]thiophene-2-carbonyl)guanidine, methanesulfonate, NHE-1 Inhibitor
      References
      ReferencesLee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.
      Product Information
      CAS number861218-38-4
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₁H₈N₄OS • CH₃SO₃H
      Chemical formulaC₁₁H₈N₄OS • CH₃SO₃H
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInhibits NHE-1-meidated pH recovery after acidosis
      Primary Target IC<sub>50</sub>2.0 µM against NHE-1
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      567500 0

      Documentation

      Na+/H+ Exchanger Isoform-1 Inhibitor - CAS 861218-38-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      567500

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms(4-Cyanobenzo[b]thiophene-2-carbonyl)guanidine, methanesulfonate, NHE-1 Inhibitor
      DescriptionA cell-permeable acylguanidine compound that inhibits NHE-1-meidated pH recovery after acidosis in PS120 cells (IC50 = 2.0 µM). Shown exhibit cardioprotective efficacy both in an isolated rat heart ischemia model in vitro and in a rat myocardial infarction model in vivo.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number861218-38-4
      Chemical formulaC₁₁H₈N₄OS • CH₃SO₃H
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months.
      Toxicity Harmful
      ReferencesLee, S., et al. 2005. Bioorg. Med. Chem. Lett. 15, 2998.