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349254 NS-398 - CAS 123653-11-2 - Calbiochem

A cell-permeable selective inhibitor of COX-2 in vitro.

NS-398 - CAS 123653-11-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide

Primary Target: COX-2
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349254
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
123653-11-2C₁₃H₁₈N₂O₅S

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349254-5MG
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      Description
      OverviewA cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
      Catalogue Number349254
      Brand Family Calbiochem®
      SynonymsN-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
      References
      ReferencesOuellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259.
      Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105.
      Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.
      Product Information
      CAS number123653-11-2
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₃H₁₈N₂O₅S
      Chemical formulaC₁₃H₁₈N₂O₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-2
      Primary Target IC<sub>50</sub>3.8 µM against COX-2
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      349254-5MG 04055977193213

      Documentation

      NS-398 - CAS 123653-11-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      NS-398 - CAS 123653-11-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      349254

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ouellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259.
      Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105.
      Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-July-2008 RFH
      SynonymsN-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
      DescriptionA cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC50 = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes.
      FormPale yellow solid
      CAS number123653-11-2
      Chemical formulaC₁₃H₁₈N₂O₅S
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (20 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Standard Handling
      ReferencesOuellet, M., and Percival, M.D. 1995. Biochem. J. 306, 247.
      Futaki, N., et al. 1994. Prostaglandins 47, 55.
      Arai, I., et al. 1993. Res. Comm. Chem. Pathol. Pharmacol. 81, 259.
      Futaki, N., et al. 1993. Gen. Pharmacol. 24, 105.
      Futaki, N., et al. 1993. J. Pharm. Pharmacol. 45, 753.