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454586 NMDAR2C/2D Inhibitor, DQP-1105 - CAS 380560-89-4 - Calbiochem

The NMDAR2C/2D Inhibitor, DQP-1105 controls the biological activity of NMDAR2C/2D. This small molecule/inhibitor is primarily used for Neuroscience applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: DQP-1105, NMDA Antagonist IV

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454586
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Tableau de caractéristiques principal

CAS #Empirical Formula
380560-89-4C₂₉H₂₄BrN₃O₄

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454586-10MG
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      Description
      OverviewA dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.
      Catalogue Number454586
      Brand Family Calbiochem®
      SynonymsDQP-1105, NMDA Antagonist IV
      References
      ReferencesAcker, T., et al. 2011. Mol. Pharmacol. 80, 782.
      Product Information
      CAS number380560-89-4
      FormYellow-white solid
      Hill FormulaC₂₉H₂₄BrN₃O₄
      Chemical formulaC₂₉H₂₄BrN₃O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      454586-10MG 04055977204193

      Documentation

      NMDAR2C/2D Inhibitor, DQP-1105 - CAS 380560-89-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      NMDAR2C/2D Inhibitor, DQP-1105 - CAS 380560-89-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      454586

      Références bibliographiques

      Aperçu de la référence bibliographique
      Acker, T., et al. 2011. Mol. Pharmacol. 80, 782.

      Brochure

      Titre
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-May-2012 JSW
      SynonymsDQP-1105, NMDA Antagonist IV
      DescriptionA dihydroquinilone-pyrazoline NMDA antagonist, which is selective for NMDA receptors that are comprised of recombinant subunits GluN1/GluN2C (IC50 = 5.4 µM) and GluN1/GluN2D (2.2 µM) over GluN1/GluN2B (206 µM) and GluN1/ClucN2A (undetectable) in Xenopus oocytes. Similar selectivity is observed in whole-cell HEK patch-clamp assays with IC50 values for GluN2C and GluN2D that are at least 50-fold lower than those for recombinant GluN2A, GluN2B, GluA1, or GluK2-containing receptors. It inhibits NMDA by blocking a conformational change necessary for channel opening and is non-competitive with co-agonists, glutamate and glycine.
      FormYellow-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number380560-89-4
      Chemical formulaC₂₉H₂₄BrN₃O₄
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml; pale yellow solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesAcker, T., et al. 2011. Mol. Pharmacol. 80, 782.