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530655 Mitochondrial GPDH Inhibitor, iGP-1 - CAS 27031-00-1 - Calbiochem

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CAS #Empirical Formula
27031-00-1C₁₇H₁₅N₃O₃

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5.30655.0001
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      Description
      OverviewA cell-permeable benzimidazolyl-phenylamidosuccinate compound that acts as a potent, selective, and dose-dependent inhibitor against mitochondrial, but not cytosolic, sn-glycerol-3-phosphate dehydrogenase (IC50 against mGPDH = 6.3 µM). Shown to directly interact with a single, allosteric binding site on mGPDH and displays mixed type of inhibition kinetics (Kic = 9.5 µM and Kiu = 14.6 µM, glycerol phosphate/GP-competitive against free and GP-uncompetitive against GP-bound mGPDH). Reduces H2O2 production by IQ site (IC50 = 13.6 µM) and inhibits ΔΨm driven by low concentrations of succinate (0.5 µM), but does not inhibit glutamate-, malate-, pyruvate-, or palmityoylcarnitine-driven ΔΨm. Does not prevent pyruvate uptake into cells or mitochondria and has no direct effect on Glycolysis in synaptosomes.
      Catalogue Number530655
      Brand Family Calbiochem®
      SynonymsN-(4-(1H-Benzoimidazol-2-yl)-phenyl)-succinamic acid, Mitochondrial sn-Glycerol-3-Phosphate Dehydrogenase Inhibitor, mGPDH Inhibitor, inhibitor of mGPDH 1, iGP1
      References
      ReferencesOrr, A.L., et al. 2014. PLoS One 9, e89938.
      Product Information
      CAS number27031-00-1
      FormBeige solid
      Hill FormulaC₁₇H₁₅N₃O₃
      Chemical formulaC₁₇H₁₅N₃O₃
      Quality LevelMQ100
      Biological Information
      Primary TargetmGPDH
      Primary Target IC<sub>50</sub>6.3 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      5.30655.0001 04055977260427