474790 Sigma-AldrichMG-132 - CAS 133407-82-6 - Calbiochem
A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM).
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Synonymes: Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 133407-82-6 | C₂₆H₄₁N₃O₅ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 474790-10MG |
|
Ampoule plast. | 10 mg |
|
— | |
| 474790-1MG |
|
Ampoule plast. | 1 mg |
|
— | |
| 474790-20MG |
|
20 mg |
|
— | ||
| 474790-5MG |
|
Ampoule plast. | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is ≥98% pure by HPLC. A material with ≥95% purity by HPLC (Cat. No. 474787) is also available. |
| Catalogue Number | 474790 |
| Brand Family | Calbiochem® |
| Synonyms | Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI |
| Product Information | |
|---|---|
| CAS number | 133407-82-6 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₂₆H₄₁N₃O₅ |
| Chemical formula | C₂₆H₄₁N₃O₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | proteasome |
| Primary Target IC<sub>50</sub> | 3 µM against NF-κB activation |
| Primary Target K<sub>i</sub> | 4 nM against proteasome |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Peptide Sequence | Z-Leu-Leu-Leu-CHO |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 474790-10MG | 04055977185485 |
| 474790-1MG | 07790788050436 |
| 474790-20MG | 04055977185492 |
| 474790-5MG | 07790788050443 |