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ASK26 MDM2 Antibody Sampler Kit-Human

MDM2 Antibody Sampler Kit-Human : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Anti-Murine Double Minute Chromosome-2

ASK26
  
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      Aperçu

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      Contains 20 µg of each of the following antibodies: Anti-MDM2 (Cat. Nos. OP144, OP145, and OP146). Please see individual product descriptions for more information.
      Catalogue NumberASK26
      Brand Family Calbiochem®
      SynonymsAnti-Murine Double Minute Chromosome-2
      Application Data
      References
      ReferencesMarchetti, A., et al. 1995. J. Pathol. 175, 31.
      Barak, Y., et al. 1993. EMBO J. 12, 461.
      Ladanyi, M., et al. 1993. Cancer Res. 53, 16.
      Leach, F. S., et al. 1993. Cancer Res. 53, 2231.
      Oliner, J. D., et al. 1993. Nature 362, 857.
      Momand, J., et al. 1992. Cell 69, 1237.
      Oliner, J. D., et al. 1992. Nature 358, 80.
      Fakharzadeh, S. S., et al. 1991. EMBO J. 10, 1565.
      Product Information
      FormLiquid
      FormulationIn buffer, 50% glycerol.
      PreservativeNone
      Applications
      Application NotesImmunoblotting (see below)
      Immunofluorescence (see below)
      Immunoprecipitation (see below)
      Paraffin Sections (see below)
      Application CommentsAntibodies should be titrated for optimal results in individual systems.
      Biological Information
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      ASK26 0

      Documentation

      MDM2 Antibody Sampler Kit-Human Certificats d'analyse

      TitreNuméro de lot
      ASK26

      Références bibliographiques

      Aperçu de la référence bibliographique
      Marchetti, A., et al. 1995. J. Pathol. 175, 31.
      Barak, Y., et al. 1993. EMBO J. 12, 461.
      Ladanyi, M., et al. 1993. Cancer Res. 53, 16.
      Leach, F. S., et al. 1993. Cancer Res. 53, 2231.
      Oliner, J. D., et al. 1993. Nature 362, 857.
      Momand, J., et al. 1992. Cell 69, 1237.
      Oliner, J. D., et al. 1992. Nature 358, 80.
      Fakharzadeh, S. S., et al. 1991. EMBO J. 10, 1565.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-February-2008 JSW
      SynonymsAnti-Murine Double Minute Chromosome-2
      ApplicationImmunoblotting (see below)
      Immunofluorescence (see below)
      Immunoprecipitation (see below)
      Paraffin Sections (see below)
      Application Data
      DescriptionSet of 3 purified mouse monoclonal antibodies that recognize MDM2.
      BackgroundIncreased expression of a gene termed MDM2, first identified in mouse as a small acentromeric extra-chromosomal element, was shown to become oncogenic upon amplification and tumorigenic when over-expressed in NIH3T3 and Rat2 cells. The human homolog of MDM2 gene has been isolated and mapped to chromosome 12q13-q14, a region that is found to be amplified in human sarcomas. Sequence analysis of the murine, rat, and human MDM2 genes suggests that MDM2 may be involved in transcriptional regulation in part by forming a stable complex with p53. Over-expression of MDM2 inhibits the ability of wild type p53 to stimulate expression of target genes, and this inhibition appears to result from MDM2 binding to the acidic activation domain of p53, thereby preventing p53 from directly contacting the transcriptional machinery. Interestingly, wild type p53 appears to positively regulate expression of the MDM2 gene. MDM2 amplification has been observed in sarcomas, and direct analysis of the MDM2 and p53 genes in sarcomas indicates that one or the other but not both of these genes is mutated in 70% of the tumors.
      Specieshuman
      FormLiquid
      FormulationIn buffer, 50% glycerol.
      Concentration Label Please refer to vial label for lot-specific concentration
      PreservativeNone
      CommentsAntibodies should be titrated for optimal results in individual systems.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing intitial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesMarchetti, A., et al. 1995. J. Pathol. 175, 31.
      Barak, Y., et al. 1993. EMBO J. 12, 461.
      Ladanyi, M., et al. 1993. Cancer Res. 53, 16.
      Leach, F. S., et al. 1993. Cancer Res. 53, 2231.
      Oliner, J. D., et al. 1993. Nature 362, 857.
      Momand, J., et al. 1992. Cell 69, 1237.
      Oliner, J. D., et al. 1992. Nature 358, 80.
      Fakharzadeh, S. S., et al. 1991. EMBO J. 10, 1565.