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428021 Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem

Latrunculin A, CAS 76343-93-6, is a cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (KD = 200 nM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: G-actin
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428021
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
76343-93-6C₂₂H₃₁NO₅S

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428021-100UG
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      Description
      OverviewA cell-permeable marine toxin that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos. A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428026 in DMSO is also available.
      Catalogue Number428021
      Brand Family Calbiochem®
      References
      ReferencesAyscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
      Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
      Spector, I., et al. 1983. Science 219, 493.
      Product Information
      CAS number76343-93-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₃₁NO₅S
      Chemical formulaC₂₂H₃₁NO₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetG-actin
      Primary Target IC<sub>50</sub>Kd = 200 nM in formation of a 1:1 complex with monomeric G-actin
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      428021-100UG 07790788050214

      Documentation

      Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Latrunculin A, Latrunculia magnifica - CAS 76343-93-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      428021

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ayscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
      Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
      Spector, I., et al. 1983. Science 219, 493.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-March-2024 JSW
      DescriptionA cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (Kd = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number76343-93-6
      Chemical formulaC₂₂H₃₁NO₅S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 8378
      ReferencesAyscough, K.R., et al. 1997. J. Cell Biol. 137, 399.
      Spector, I., et al. 1989. Cell Motil. Cytoskeleton 13, 127.
      Coue, M., et al. 1987. FEBS Lett. 213, 316.
      Schatten, G., et al. 1986. Exp. Cell Res. 166, 191.
      Spector, I., et al. 1983. Science 219, 493.