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422720 L-744,832 - CAS 1177806-11-9 - Calbiochem

A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties.

L-744,832 - CAS 1177806-11-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382

Primary Target: Farnesyltransferase (FTase)
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      1177806-11-9C₂₆H₄₅N₃O₆S₂ · 2HCl
      Description
      OverviewA cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.
      Catalogue Number422720
      Brand Family Calbiochem®
      Synonyms(2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382
      References
      ReferencesLaw, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
      Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
      Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
      Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
      Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
      Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
      Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.
      Product Information
      CAS number1177806-11-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₄₅N₃O₆S₂ · 2HCl
      Chemical formulaC₂₆H₄₅N₃O₆S₂ · 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFarnesyltransferase (FTase)
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      422720 0

      Documentation

      L-744,832 - CAS 1177806-11-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      L-744,832 - CAS 1177806-11-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      422720

      Références bibliographiques

      Aperçu de la référence bibliographique
      Law, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
      Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
      Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
      Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
      Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
      Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
      Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      Synonyms(2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382
      DescriptionA potent, cell-permeable, and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor that blocks p70s6k activation and DNA synthesis and promote apoptosis in transgenic mice. Induces p21 expression and arrests cell in the G1 phase of the cell cycle. Also shown to act synergistically with paclitaxel and epothilones in inhibiting tumor growth and arresting cells in metaphase. Also mimics a number of the effects exhibited by Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropirate activation of the mTOR/p70s6k pathway in animal models.
      FormWhite solid
      CAS number1177806-11-9
      Chemical formulaC₂₆H₄₅N₃O₆S₂ · 2HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mg/ml) or H₂O (15 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLaw, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
      Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
      Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
      Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
      Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
      Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
      Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.