Millipore Sigma Vibrant Logo

420101 JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem

The JAK3 Inhibitor I, also referenced under CAS 202475-60-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131

Primary Target: Janus family kinase 3
View Products on Sigmaaldrich.com
420101
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
202475-60-3C₁₆H₁₅N₃O₃

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
420101-5MG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Ampoule plast. 5 mg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3; IC50 = 78 µM). Has no effect on JAK1, JAK2, or Zap/Syk or Src tyrosine kinases. Acts as a potent inhibitor of glioblastoma cell adhesion and migration. Also reported to block thrombin-induced platelet aggregation.
      Catalogue Number420101
      Brand Family Calbiochem®
      Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
      References
      ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
      Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
      Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
      Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.
      Product Information
      CAS number202475-60-3
      ATP CompetitiveY
      FormWhite to off-white solid
      Hill FormulaC₁₆H₁₅N₃O₃
      Chemical formulaC₁₆H₁₅N₃O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJanus family kinase 3
      Primary Target IC<sub>50</sub>78 µM against Janus family kinase 3
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420101-5MG 04055977187892

      Documentation

      JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      420101

      Références bibliographiques

      Aperçu de la référence bibliographique
      Tibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
      Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
      Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
      Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.

      Informations techniques

      Titre
      JAK/STAT Signaling Research Focus
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms4-(4ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline, WHI-P131
      DescriptionA cell-permeable, reversible, potent, ATP-competitive, and specific inhibitor of JAK3 (Janus family kinase 3) (IC50 = 78 µM). Has no effect on either JAK1, JAK2, Zap/Syk or Src kinases. Blocks thrombin-induced platelet aggregation.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number202475-60-3
      Chemical formulaC₁₆H₁₅N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTibbles, H.E., et al. 2001. J. Biol. Chem. 276, 17815.
      Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
      Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
      Narla, R.K., et al. 1998. Clin. Cancer Res. 4, 2463.