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662009 InSolution™ U0126 - CAS 109511-58-2 - Calbiochem

A potent and specific inhibitor of MEK1 and MEK2 .

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662009
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
109511-58-2C₁₈H₁₆N₆S₂•½C₂H₅OH

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662009-5MG
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      Description
      OverviewA potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
      Catalogue Number662009
      Brand Family Calbiochem®
      References
      ReferencesDuncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2839.
      Product Information
      CAS number109511-58-2
      FormLiquid
      FormulationA 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
      Hill FormulaC₁₈H₁₆N₆S₂•½C₂H₅OH
      Chemical formulaC₁₈H₁₆N₆S₂•½C₂H₅OH
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      662009-5MG 04055977261035

      Documentation

      InSolution™ U0126 - CAS 109511-58-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ U0126 - CAS 109511-58-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      662009

      Références bibliographiques

      Aperçu de la référence bibliographique
      Duncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2839.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-January-2012 RFH
      DescriptionA potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
      FormLiquid
      FormulationA 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number109511-58-2
      Chemical formulaC₁₈H₁₆N₆S₂•½C₂H₅OH
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot into precooled vials, freeze immediately at (-70°C).
      Toxicity Irritant
      ReferencesDuncia, J.V., et al. 1998. Bioorg. Med. Chem. Lett. 8, 2839.