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420097 InSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem

InSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X

Primary Target: murine JAK1
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420097
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
457081-03-7C₁₈H₁₆FN₃O

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420097-500UG
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      Description
      Catalogue Number420097
      Brand Family Calbiochem®
      Synonyms2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
      References
      ReferencesThompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.
      Product Information
      CAS number457081-03-7
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
      Hill FormulaC₁₈H₁₆FN₃O
      Chemical formulaC₁₈H₁₆FN₃O
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).
      Biological Information
      Primary Targetmurine JAK1
      Primary Target IC<sub>50</sub>15 nM, 1 nM against murine JAK1 and JAK2, respectively; 1 nM against Tyk2
      Primary Target K<sub>i</sub> 5 nM against JAK3
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420097-500UG 04055977187861

      Documentation

      InSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      420097

      Références bibliographiques

      Aperçu de la référence bibliographique
      Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.

      Informations techniques

      Titre
      JAK/STAT Signaling Research Focus
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-February-2009 JSW
      Synonyms2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
      DescriptionA potent inhibitor of Janus Protein tyrosine Kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). It inhibits other kinases only at much higher concentrations. Also inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks the phosphorylation of STAT5.
      FormLiquid
      FormulationA 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number457081-03-7
      Chemical formulaC₁₈H₁₆FN₃O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Irritant
      ReferencesThompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219.