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400092 InSolution™ HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

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Synonymes: Hypoxia-Inducible Factor-1 Inhibitor, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester

Primary Target: HIF-1
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      934593-90-5C₂₆H₂₉NO₅
      Description
      OverviewA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
      Catalogue Number400092
      Brand Family Calbiochem®
      SynonymsHypoxia-Inducible Factor-1 Inhibitor, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester
      References
      ReferencesNaik, R., et. al. 2012. J. Med. Chem. 55, 10564.
      Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
      Product Information
      CAS number934593-90-5
      FormLiquid
      FormulationA 25 mM (5 mg/459 µL) solution of HIF-1 Inhibitor (Cat. No. 400083) in DMSO.
      Hill FormulaC₂₆H₂₉NO₅
      Chemical formulaC₂₆H₂₉NO₅
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHIF-1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      400092 0

      Documentation

      Références bibliographiques

      Aperçu de la référence bibliographique
      Naik, R., et. al. 2012. J. Med. Chem. 55, 10564.
      Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-February-2013 JSW
      SynonymsHypoxia-Inducible Factor-1 Inhibitor, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester
      DescriptionA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
      FormLiquid
      FormulationA 25 mM (5 mg/459 µL) solution of HIF-1 Inhibitor (Cat. No. 400083) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number934593-90-5
      Chemical formulaC₂₆H₂₉NO₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesNaik, R., et. al. 2012. J. Med. Chem. 55, 10564.
      Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
      Lee, K., et al. 2007. J. Med. Chem. 50, 1675.