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218861 InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem

The InSolution™ Casein Kinase II Inhibitor III, TBCA, also referenced under CAS 934358-00-6, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid

Primary Target: CKII
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218861
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
934358-00-6C₉H₄Br₄O₂

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218861-5MG
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      Description
      OverviewA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
      Catalogue Number218861
      Brand Family Calbiochem®
      Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
      References
      ReferencesPagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.
      Product Information
      CAS number934358-00-6
      FormLiquid
      FormulationA 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
      Hill FormulaC₉H₄Br₄O₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCKII
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      218861-5MG 04055977201970

      Documentation

      InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ Casein Kinase II Inhibitor III, TBCA - CAS 934358-00-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      218861

      Références bibliographiques

      Aperçu de la référence bibliographique
      Pagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-September-2012 JSW
      Synonyms(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic acid
      DescriptionA cell-permeable tetrabrominated cinnamic acid compound that acts as a potent and ATP-competitive inhibitor of Casein Kinase II (IC50 = 110 nM, Ki = 77 nM) with greater selectivity than TBB (Cat. No. 218697 and Cat. No. 218708) and DMAT (Cat. No. 218699 and Cat. No. 218706) against a panel of 28 commonly studied kinases. Shown to efficiently induce apoptosis in Jurkat cells (DC50 = 7.7 µM). The solid form of this compound (Cat. No. 218710) is also available.
      FormLiquid
      FormulationA 25 mM (5 mg/431 µL) solution of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number934358-00-6
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesPagano, M.A., et al. 2006. Chembiochem,/i> 8, 129.