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420326 IRTK Activator III, DDN - Calbiochem

The IRTK Activator III, DDN modulates the biological activity of IRTK. This small molecule/inhibitor is primarily used for Biochemicals applications.

IRTK Activator III, DDN - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₁₄H₈Cl₂O₆
      Description
      Overview

      This product has been discontinued.



      An orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
      Catalogue Number420326
      Brand Family Calbiochem®
      Synonyms5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
      References
      ReferencesHe, K., et al. 2011. J. Biol. Chem. 286, 37379.
      Product Information
      FormPale yellow-green powder
      Hill FormulaC₁₄H₈Cl₂O₆
      Chemical formulaC₁₄H₈Cl₂O₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420326 0

      Documentation

      IRTK Activator III, DDN - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      IRTK Activator III, DDN - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      420326

      Références bibliographiques

      Aperçu de la référence bibliographique
      He, K., et al. 2011. J. Biol. Chem. 286, 37379.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-August-2012 JSW
      Synonyms5,8-Diacetyloxy-2,3-dichloro-1,4-naphthoquinone
      DescriptionAn orally bioavilable diacetyloxy-naphthoquinone compound that directly targets insulin receptor tyrosine kinase (IRTK) domain and specifically increases IR kinase activity with no effect on IGF-1R and EGFR. Shown to rapidly phosphorylate IR (Tyr1146 and Tyr1158/1162/1163) and IRS-1 and selectively activate insulin signaling Akt (Thr473) and ERK pathways in CHO-IGF-IR cells at 5 µM. Sensitizes insulin action, enhances glucose uptake in differentiated 3T3-L1 adipocytes and decreases blood glucose levels in both normal and diabetic C57BL/6J mice (20 mg/kg, p.o.).
      FormPale yellow-green powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₈Cl₂O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from moisture
      Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHe, K., et al. 2011. J. Biol. Chem. 286, 37379.