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400086 HIF Inhibitor VI - Calbiochem

The HIF-1 Inhibitor, NSC-134754 controls the biological activity of HIF-1. This small molecule/inhibitor is primarily used for Cell Structure applications.

HIF Inhibitor VI - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: NSC-134754

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400086
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₇H₃₄N₂O₂

Prix & Disponibilité

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400086-5MG
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      Description
      OverviewA cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
      Catalogue Number400086
      Brand Family Calbiochem®
      SynonymsNSC-134754
      References
      ReferencesChau, N.M., et al. 2005. Cancer Res. 65, 4918.
      Product Information
      FormBrown solid
      Hill FormulaC₂₇H₃₄N₂O₂
      Chemical formulaC₂₇H₃₄N₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      400086-5MG 04055977212334

      Documentation

      HIF Inhibitor VI - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      HIF Inhibitor VI - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      400086

      Références bibliographiques

      Aperçu de la référence bibliographique
      Chau, N.M., et al. 2005. Cancer Res. 65, 4918.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2013 JSW
      SynonymsNSC-134754
      DescriptionA cell-permeable emetan derivative that selectively reduces HIF-1 activity by 73% in a luciferase reporter assay, and blocks HIF-1α protein induction in response to DFX, hypoxia, and IGF-1 in U2OS-HRE-luc cells at 10 µM, without significantly inhibiting cell growth. Furthermore, it is shown to completely block HIF-1α induced by IGF-1 in HCT116 human colon carcinoma cells.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₇H₃₄N₂O₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesChau, N.M., et al. 2005. Cancer Res. 65, 4918.