Millipore Sigma Vibrant Logo

345700 Ganciclovir - CAS 82410-32-0 - Calbiochem

Ganciclovir, CAS 82410-32-0, is a nucleoside analog related to Acyclovir. Acts as a prodrug that is activated by phosphorylation. Inhibits the replication of cytomegalovirus (CMV; IC50 = 10 nM).

Ganciclovir - CAS 82410-32-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

Primary Target: Acts as a prodrug that is activated by phosphorylation
View Products on Sigmaaldrich.com
345700
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
82410-32-0C₉H₁₃N₅O₄

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
345700-50MG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Flacon en verre 50 mg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewA nucleoside analog structurally related to Acyclovir (Cat. No. 114798). Acts as a prodrug that is activated by phosphorylation. Has been used in the study of “suicide” gene therapy in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.
      Catalogue Number345700
      Brand Family Calbiochem®
      Synonyms9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
      References
      ReferencesAghi, M., et al. 2000. J. Gene Med. 2, 148.
      Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
      Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
      Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
      Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
      Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
      Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.
      Product Information
      CAS number82410-32-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₉H₁₃N₅O₄
      Chemical formulaC₉H₁₃N₅O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGanciclovir, CAS 82410-32-0, is a nucleoside analog related to Acyclovir. Acts as a prodrug that is activated by phosphorylation. Inhibits the replication of cytomegalovirus (CMV; IC50 = 10 nM).
      Biological Information
      Primary TargetActs as a prodrug that is activated by phosphorylation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMF8407000
      Safety Information
      R PhraseR: 46-60-61

      May cause heritable genetic damage.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 36/37/39-45-53

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      345700-50MG 04055977194500

      Documentation

      Ganciclovir - CAS 82410-32-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      345700

      Références bibliographiques

      Aperçu de la référence bibliographique
      Aghi, M., et al. 2000. J. Gene Med. 2, 148.
      Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
      Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
      Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
      Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
      Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
      Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-November-2007 JSW
      Synonyms9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
      DescriptionA nucleoside analog that is structurally related to Acyclovir (Cat. No. 114798). Acts as a pro-drug that is activated by phosphorylation. It has been used in the study of "suicide gene therapy" in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus thymidine kinase (TK), the non-toxic pro-drug is converted to the phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the dividing malignant cells. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Has also been used to study the loss of telomers and to evaluate the sensitivity of viruses to anti-viral agents.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number82410-32-0
      RTECSMF8407000
      Chemical formulaC₉H₁₃N₅O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (2 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 4363
      ReferencesAghi, M., et al. 2000. J. Gene Med. 2, 148.
      Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
      Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
      Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
      Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
      Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
      Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.