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370700 GW9662 - CAS 22978-25-2 - Calbiochem

GW9662 - CAS 22978-25-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-Chloro-5-nitro-N-phenylbenzamide

Primary Target: PPARγ
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      22978-25-2C₁₃H₉ClN₂O₃
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-α (LXRα), retinoic acid receptor (RAR), retinoid X receptor-α (RXRα) and thyroid receptors α and β (TRα and TRβ).
      Catalogue Number370700
      Brand Family Calbiochem®
      Synonyms2-Chloro-5-nitro-N-phenylbenzamide
      References
      ReferencesLeesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
      Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
      Huang, J.T., et al. 1999. Nature 400, 378.
      Product Information
      CAS number22978-25-2
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₁₃H₉ClN₂O₃
      Chemical formulaC₁₃H₉ClN₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetPPARγ
      Primary Target IC<sub>50</sub>3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      370700 0

      Documentation

      GW9662 - CAS 22978-25-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      370700

      Références bibliographiques

      Aperçu de la référence bibliographique
      Leesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
      Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
      Huang, J.T., et al. 1999. Nature 400, 378.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2016 JSW
      Synonyms2-Chloro-5-nitro-N-phenylbenzamide
      DescriptionA cell-permeable, selective, and irreversible PPAPγ antagonist (IC50 = 3.3 nM, 32 nM, and 2.0 µM for PPARγ, PPARα, and PPARδ, respectively) that is reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor α (LXRα), retinoic acid receptor (RAR), retinoid X receptor α (RXRα), or thyroid receptors α and β (TRα and TRβ).
      FormCrystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number22978-25-2
      Chemical formulaC₁₃H₉ClN₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml) or Methanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLeesnitzer, L.M., et al. 2002. Biochemistry 41, 6640.
      Willson, T.M., et al. 2000. J. Med. Chem. 43, 527.
      Huang, J.T., et al. 1999. Nature 400, 378.