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361547 GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone

Primary Target: Gsk-3β
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      62673-69-2C₆H₃Br₂ClOS
      Description
      Overview

      This product has been discontinued.



      A thienyl α-chloromethyl ketone compound that acts as a cell-permeable, irreversible, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
      Catalogue Number361547
      Brand Family Calbiochem®
      Synonyms2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
      References
      ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.
      Product Information
      CAS number62673-69-2
      ATP CompetitiveN
      FormOrange solid
      Hill FormulaC₆H₃Br₂ClOS
      Chemical formulaC₆H₃Br₂ClOS
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGsk-3β
      Primary Target IC<sub>50</sub>1 µM against Gsk-3β
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      361547 0

      Documentation

      GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      GSK-3β Inhibitor VI - CAS 62673-69-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      361547

      Références bibliographiques

      Aperçu de la référence bibliographique
      Conde, S., et al. 2003. J. Med. Chem. 46, 4631.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      Synonyms2-Chloro-1-(4,5-dibromo-thiophen-2-yl)-ethanone
      DescriptionA cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 1 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.
      FormOrange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number62673-69-2
      Chemical formulaC₆H₃Br₂ClOS
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml). Use fresh, anhydrous DMSO only.
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in DMSO, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 1 week at -20°C. For increased stability reconstitute in chloroform, aliquot, dry under a stream of inert gas, and freeze (-20°C). Reconstitute in fresh DMSO just prior to use.
      Toxicity Standard Handling
      ReferencesConde, S., et al. 2003. J. Med. Chem. 46, 4631.