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344935 Furin Substrate, Fluorogenic - Calbiochem

A fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 10⁴ s⁻¹M⁻¹).

Furin Substrate, Fluorogenic - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
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344935
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344935-5MG
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      		 Ampoule plast. 5 mg
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      Description
      OverviewA fluorogenic substrate for furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km ~ 2 x 104 s-1M-1).
      Catalogue Number344935
      Brand Family Calbiochem®
      References
      ReferencesLamango, N.S., et al. 1996. Arch. Biochem. Biophys. 330, 238.
      Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₇H₅₇N₁₃O₉
      Chemical formulaC₃₇H₅₇N₁₃O₉
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFluorogenic substrate for furin
      Primary Target IC<sub>50</sub>kcat/Km ~ 2 x 104 s-1M-1 for furin
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequencePyr-Arg-Thr-Lys-Arg-AMC
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      344935-5MG 04055977194418

      Documentation

      Furin Substrate, Fluorogenic - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Furin Substrate, Fluorogenic - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      344935

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lamango, N.S., et al. 1996. Arch. Biochem. Biophys. 330, 238.
      Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2008 RFH
      DescriptionA fluorogenic substrate for furin (kcat/Km ~2 X 104 M-1 s-1), a mammalian homolog of the yeast Kex2 endoprotease. Also serves as a substrate for related protein, prohormone convertase 2 (PC2) (kcat/Km ~6 X 103 M-1 s-1). Excitation max: ~360-380 nm; emission max: ~430-460 nm).
      FormWhite solid
      FormulationSupplied as a trifluoroacetate salt.
      Recommended reaction conditions20 nM of substrate in a 250 µl final reaction volume. Buffer:100 mM MES/NaOH, 1 mM CaCl2, pH 7.0. Temperature: 37°C. Duration of incubation: 1-4 h. Reaction can be terminated by adding 3 ml of 5 mM EDTA and the amount of AMC released is measured.
      Chemical formulaC₃₇H₅₇N₁₃O₉
      Peptide SequencePyr-Arg-Thr-Lys-Arg-AMC
      Purity≥95% by HPLC
      SolubilityH₂O (10 mg/ml) or DMSO
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLamango, N.S., et al. 1996. Arch. Biochem. Biophys. 330, 238.
      Hatsuzawa, K., et al. 1992. J. Biol. Chem. 267, 16094.