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504539 Eliprodil - CAS 119431-25-3 - Calbiochem

Eliprodil - CAS 119431-25-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: α-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX

Primary Target: NMDA receptors
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504539
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Tableau de caractéristiques principal

CAS #Empirical Formula
119431-25-3C₂₀H₂₃ClFNO

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      Description
      OverviewA negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, >100, and >100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for α1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain α receptors. Blocks neuronal voltage-gated Ca2+
      Catalogue Number504539
      Brand Family Calbiochem®
      Synonymsα-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX
      References
      ReferencesLengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
      Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
      Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
      Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.
      Product Information
      CAS number119431-25-3
      FormWhite solid
      Hill FormulaC₂₀H₂₃ClFNO
      Chemical formulaC₂₀H₂₃ClFNO
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>1, > 100, and > 100 →M for NR2B, NR2A, and NR2C, respectively.
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.04539.0001 04055977244878

      Documentation

      Eliprodil - CAS 119431-25-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
      Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
      Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
      Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-June-2013 JSW
      Synonymsα-(4-Chlorophenyl)-4-[(4-fluorophenyl)methyl]-1-piperidineethanol, NMDA Antagonist IX
      DescriptionA negative allosteric modulator selective for NR2B containing NMDA receptors (IC50 = 1, > 100, and > 100 µM for NR2B, NR2A, and NR2C, respectively). Also a potent ligand for ς1 receptor (Ki = 0.013 µM), one of the two types of unique non-opioid, non-phencyclidine brain ς receptors. Blocks neuronal voltage-gated Ca2+ channels and selectively inhibits the rapid component of the delayed rectifier K+ current (IKr). A neuroprotective agent in acute ischemic stroke. Prolongs the QT interval in EKG.
      FormWhite solid
      CAS number119431-25-3
      Chemical formulaC₂₀H₂₃ClFNO
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (17 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLengyel, C., et al. 2004. Br. J. Pharmacol. 143, 152.
      Nikam, S., et al. 2002. Curr Pharm Des. 8, 845. Whittemore, E., et al. 1997. J. Pharmacol. Exp. Ther. 282, 326.M
      Bath, C., et al. 1996. Eur. J. Pharmacol. 299, 103.
      Carter, C., et al. 1994. Neuropsychopharmacol. 11, 257.