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251600 Daidzein - CAS 486-66-8 - Calbiochem

Inactive analog of Genistein.

Daidzein - CAS 486-66-8 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4ʹ,7-Dihydroxyisoflavone, Casein Kinase II Inhibitor X

Primary Target: MiaPaC-2, PANC-1
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251600
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
486-66-8C₁₅H₁₀O₄

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251600-25MG
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      		 Ampoule plast. 25 mg
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      Description
      OverviewInactive analog of Genistein (Cat. No. 345834). Blocks the G1 phase of the cell cycle in Swiss/3T3 cells by inhibiting casein kinase II activity. Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC50= 45 µM and 75 µM, respectively).
      Catalogue Number251600
      Brand Family Calbiochem®
      Synonyms4ʹ,7-Dihydroxyisoflavone, Casein Kinase II Inhibitor X
      References
      ReferencesGuo, J-M., et al. 2004. World J. Gastroenterol. 10, 860.
      Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
      Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol. 7, 637.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
      Product Information
      CAS number486-66-8
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₅H₁₀O₄
      Chemical formulaC₁₅H₁₀O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMiaPaC-2, PANC-1
      Primary Target IC<sub>50</sub>45 µM, 75 µM for inhibiting the growth of MiaPaC-2 and PANC-1 cells, respectively
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDJ3100040
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 24-26

      Avoid contact with skin.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. DMSO stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      251600-25MG 04055977198539

      Documentation

      Daidzein - CAS 486-66-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Daidzein - CAS 486-66-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      251600

      Références bibliographiques

      Aperçu de la référence bibliographique
      Guo, J-M., et al. 2004. World J. Gastroenterol. 10, 860.
      Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
      Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol. 7, 637.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2008 RFH
      Synonyms4ʹ,7-Dihydroxyisoflavone, Casein Kinase II Inhibitor X
      DescriptionInactive analog of genistein (Cat. No. 345834). Blocks the G1 phase of the cell cycle in Swiss 3T3 cells by inhibiting casein kinase II activity. Inhibits epidermal growth factor (EGF) receptor autophosphorylation (IC50 >300 µM). Inhibits the growth of MiaPaC-2 and PANC-1 cells (IC50= 45 µM and 75 µM, respectively).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number486-66-8
      RTECSDJ3100040
      Chemical formulaC₁₅H₁₀O₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (200 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) under an inert gas. DMSO stock solutions are stable for up to 2 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 2801
      ReferencesGuo, J-M., et al. 2004. World J. Gastroenterol. 10, 860.
      Higashi, K., and Ogawara, H. 1994. Biochim. Biophys. Acta 1221, 29.
      Lavens, S.E., et al. 1992. Am. J. Respir. Cell Mol. Biol. 7, 637.
      Akiyama, T., et al. 1987. J. Biol. Chem. 262, 5592.