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288500 DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem

A cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: DFMO, Eflornithine, RMI-71782

Primary Target: ODC
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288500
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
96020-91-6C₆H₁₂F₂N₂O₂ · HCl · H₂O

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      Description
      OverviewA cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.
      Catalogue Number288500
      Brand Family Calbiochem®
      SynonymsDFMO, Eflornithine, RMI-71782
      References
      ReferencesMeyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
      Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
      Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
      Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
      Danzin, C., et al. 1979. Life Sci. 24, 519.
      Product Information
      CAS number96020-91-6
      ATP CompetitiveN
      FormWhite powder
      Hill FormulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
      Chemical formulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetODC
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSRM2981900
      Safety Information
      R PhraseR: 40

      Limited evidence of a carcinogenic effect.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      288500-25MG 04055977197921

      Documentation

      DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      DL-α-Difluoromethylornithine, Hydrochloride - CAS 96020-91-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      288500

      Références bibliographiques

      Aperçu de la référence bibliographique
      Meyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
      Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
      Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
      Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
      Danzin, C., et al. 1979. Life Sci. 24, 519.

      Brochure

      Titre
      Pathways and Biomarkers of Oxidative Stress
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-January-2008 JSW
      SynonymsDFMO, Eflornithine, RMI-71782
      DescriptionA cell-permeable, anticancer agent that acts as a specific and irreversible inhibitor of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis. Inhibits B16 melanoma-induced angiogenesis in ovo and proliferation of vascular endothelial cells in vitro.
      FormWhite powder
      CAS number96020-91-6
      RTECSRM2981900
      Chemical formulaC₆H₁₂F₂N₂O₂ · HCl · H₂O
      Structure formulaStructure formula
      Purity≥99% by TLC
      SolubilityH₂O (1 mg/ml) or Methanol (25 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 3522
      ReferencesMeyskens, F.L., Jr., and Gerner, E.W. 1995. J. Cell. Biochem. (Suppl.) 22, 126.
      Feuerstein, B.G., et al. 1992. Cancer Res. 52, 6782.
      Takigawa, M., et al. 1990. Cancer Res. 50, 4131.
      Weeks, C.E., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 6028.
      Danzin, C., et al. 1979. Life Sci. 24, 519.