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252801 DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem

The DGAT-1 Inhibitor, A 922500, also referenced under CAS 959122-11-3, controls the biological activity of DGAT-1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      959122-11-3C₂₆H₂₄N₂O₄
      Description
      OverviewAn orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 uM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 uM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.
      Catalogue Number252801
      Brand Family Calbiochem®
      References
      ReferencesKing, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.
      Product Information
      CAS number959122-11-3
      FormLight yellow solid
      Hill FormulaC₂₆H₂₄N₂O₄
      Chemical formulaC₂₆H₂₄N₂O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      252801 0

      Documentation

      DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      DGAT-1 Inhibitor, A 922500 - CAS 959122-11-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      252801

      Références bibliographiques

      Aperçu de la référence bibliographique
      King, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-December-2015 JSW
      DescriptionAn orally, bioavailable human and mouse diacylglycerol acyltransferase DGAT-1 inhibitor (IC50 = 9nM and 22 nM, respectively), which may target DGAT-2 (IC50 = 53 µM) and the phylogenetic family members acyl coenzyme A cholesterol acyltransferase-1 and -2 (IC50 = 296 µM) with equal or less potencies. In vivo activities indicate an effective reduction in serum triglycerides, FFA concentrations, and total cholesterol by 53%, 55% and 25%, respectively, compared to baseline, when administered orally at 3 mg/kg daily dosages in Dyslipidemic Hamsters. Similar reductions in triglyceride and FFA concentrations were shown in Zucker fatty rats.
      FormLight yellow solid
      CAS number959122-11-3
      Chemical formulaC₂₆H₂₄N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Regulatory Review
      ReferencesKing, A.J., et al. 2009. J. Pharmacol. Exp. Ther. 330, 526.