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234505 Compound 56 - CAS 171745-13-4 - Calbiochem

A cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (IC₅₀ = 6 pM).

Compound 56 - CAS 171745-13-4 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline

Primary Target: EGFR
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      171745-13-4C₁₈H₁₈BrN₃O₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (IC50 = 6 pM).
      Catalogue Number234505
      Brand Family Calbiochem®
      Synonyms4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
      References
      ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
      Product Information
      CAS number171745-13-4
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 5,457,105 and European Patent 0,566,266.
      FormWhite solid
      Hill FormulaC₁₈H₁₈BrN₃O₂
      Chemical formulaC₁₈H₁₈BrN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetEGFR
      Primary Target IC<sub>50</sub>6 pM against EGFR
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 40

      Limited evidence of a carcinogenic effect.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      234505 0

      Documentation

      Compound 56 - CAS 171745-13-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Compound 56 - CAS 171745-13-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      234505

      Références bibliographiques

      Aperçu de la référence bibliographique
      Bridges, A.J., et al. 1996. J. Med. Chem. 39, 267.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      Synonyms4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
      DescriptionA cell-permeable, reversible, ATP-competitive, highly potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 6 pM).
      FormWhite solid
      CAS number171745-13-4
      Chemical formulaC₁₈H₁₈BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesBridges, A.J., et al. 1996. J. Med. Chem. 39, 267.