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233165 Clioquinol - CAS 130-26-7 - Calbiochem

A metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic.

Clioquinol - CAS 130-26-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 5-Chloro-7-iodo-8-hydroxyquinoline

Primary Target: Metal ion chelator
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233165
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Tableau de caractéristiques principal

CAS #Empirical Formula
130-26-7C₉H₅ClINO

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      Description
      OverviewA metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid’s ability to clump together, apparently by trapping the Cu2+ and Zn2+ that stud these deposits. Shown to increase distal dominant axonopathy in animal models.
      Catalogue Number233165
      Brand Family Calbiochem®
      Synonyms5-Chloro-7-iodo-8-hydroxyquinoline
      References
      ReferencesMelov, S. 2002. Trends Neurosci. 25, 121.
      Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
      Helmuth, L., et al. 2000. Science 290, 1273.
      Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.
      Product Information
      CAS number130-26-7
      ATP CompetitiveN
      FormSolid
      Hill FormulaC₉H₅ClINO
      Chemical formulaC₉H₅ClINO
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMetal ion chelator
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSVC5075000
      Safety Information
      R PhraseR: 42/43-63

      May cause sensitization by inhalation and skin contact.
      Possible risk of harm to the unborn child.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      233165-1GM 04055977217766

      Documentation

      Clioquinol - CAS 130-26-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Clioquinol - CAS 130-26-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      233165

      Références bibliographiques

      Aperçu de la référence bibliographique
      Melov, S. 2002. Trends Neurosci. 25, 121.
      Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
      Helmuth, L., et al. 2000. Science 290, 1273.
      Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.

      Brochure

      Titre
      Alzheimer's Disease Brochure & Technical Guide
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2008 RFH
      Synonyms5-Chloro-7-iodo-8-hydroxyquinoline
      DescriptionA metal ion chelator that crosses the blood-brain barrier and acts as a neurotoxic antibiotic. Reported to dissolve senile plaques and reduce amyloid's ability to clump together, apparently by trapping the Cu2+ and Zn2+ that reduces the build-up of these deposits. Exhibits greater affinity for Cu2+ and Zn2+ than for Ca2+ and Mg2+. Shown to induce distal dominant axonopathy in animal models. Clioquinol treatment has been shown to be beneficial in a mouse model of Alzheimer's disease.
      FormSolid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number130-26-7
      RTECSVC5075000
      Chemical formulaC₉H₅ClINO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml), Ethanol (1 mg/ml) or Methanol (1.5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 5031
      ReferencesMelov, S. 2002. Trends Neurosci. 25, 121.
      Regland, B., et al. 2001. Dement. Geriatr. Cogn. Disord. 12, 408.
      Helmuth, L., et al. 2000. Science 290, 1273.
      Tateishi, J., et al. 2000. Neuropathology 20, Suppl: S20-4.