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219556 Ceranib-2 - Calbiochem

A cell-permeable, potent inhibitor of ceramidase (IC₅₀ = 28 mM) with anti-proliferative and proapoptotic properties.

Ceranib-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Ceranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₂₅H₁₉NO₃
      Description
      OverviewA cell-permeable, potent inhibitor of ceramidase (IC50 = 28 µM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50 = 730 nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50 mg/kg) without affecting the total body weight.
      Catalogue Number219556
      Brand Family Calbiochem®
      SynonymsCeranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III
      References
      ReferencesDraper, J., et al. 2011, Mol. Cancer Ther. 10, 2052.
      Product Information
      FormWhite powder
      Hill FormulaC₂₅H₁₉NO₃
      Chemical formulaC₂₅H₁₉NO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      219556 0

      Documentation

      Ceranib-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Ceranib-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      219556

      Références bibliographiques

      Aperçu de la référence bibliographique
      Draper, J., et al. 2011, Mol. Cancer Ther. 10, 2052.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-May-2012 JSW
      SynonymsCeranib 2, Ceranib2, 3-(3-(4-methoxyphenyl)acryloyl)-4-phenylquinolin-2(1H)-one, AC Inhibitor III, Acid Ceramidase Inhibitor III
      DescriptionA cell-permeable, potent inhibitor of ceramidase (IC50 = 28 µM) with anti-proliferative and proapoptotic properties. Shown to block the proliferation of SKVO3, ovarian adenocarcinma cells (IC50 = 730 nM) in the G2/M phase. When used in combination with paclitaxel, it increases tumor chemosentitvity and exhibits additive chemotherapeutic effects. Reduces tumor burden in Balb/c mice when administered intraperitoneally (20-50 mg/kg) without affecting the total body weight.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₁₉NO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml; clear, pale yellow solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDraper, J., et al. 2011, Mol. Cancer Ther. 10, 2052.