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217714 Cdk1/2 Inhibitor III - CAS 443798-55-8 - Calbiochem

The Cdk1/2 Inhibitor III, also referenced under CAS 443798-55-8, controls the biological activity of Cdk1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation

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Synonymes: 5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide

Primary Target: Cdk1/cyclin B, Cdk2/cyclin A
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217714
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Aperçu

Tableau de caractéristiques principal

CAS #Empirical Formula
443798-55-8C₁₅H₁₃F₂N₇O₂S₂

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217714-1MG
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      Description
      OverviewA cell-permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa, and A375 cells, respectively). Acts as a highly potent, reversible, ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A (IC50 = 600 pM and 500 pM, respectively) with selectivity over VEGF-R2 (IC50 = 32 nM), GSK-3β (IC50 = 140 nM), and a panel of eight other kinases (IC50 ≥ 1 µM).
      Catalogue Number217714
      Brand Family Calbiochem®
      Synonyms5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide
      References
      ReferencesLin, R., et al. 2005.J. Med. Chem. 48, 4208.
      Product Information
      CAS number443798-55-8
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₅H₁₃F₂N₇O₂S₂
      Chemical formulaC₁₅H₁₃F₂N₇O₂S₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCdk1/cyclin B, Cdk2/cyclin A
      Primary Target IC<sub>50</sub>20 nM, 35 nM and 92 nM for anti-proliferative properties in HCT-116, HeLa, and A375 cells, respectively; 600 pM and 500 pM, against Cdk1/cyclin B and Cdk2/cyclin A, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      217714-1MG 04055977202397