219511 Sigma-AldrichCdc2-Like Kinase Inhibitor IV, KH-CB19 - Calbiochem
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Aperçu
Tableau de caractéristiques principal
| Empirical Formula |
|---|
| C₁₅H₁₃Cl₂N₃O₂ |
| Description | |
|---|---|
| Overview | This product has been discontinued. A cell-permeable N-methylindolyl-enaminonitrile that acts as a potent inhibitor against CLK1, DYRK1A (IC50 = 19.7 and 55.2 nM, respectively), and likely CLK4, while exhibiting much lower potency against CLK3 (IC50 = 0.53 µM) and little activity toward a panel of 71 other protein kinases. Shown to be more effective than TG003 (Cat. No. 219479) in suppressing both basal and TNF-α-stimulated SRp55 and SRp75 phosphorylation, as well as human tissue factor spliced variants, flTF and asHTF, mRNA levels in human microvascular endothelial cells HMEC-1 (5 to 10 µM). |
| Catalogue Number | 219511 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-Ethyl-3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate, Clk Inhibitor IV |
| References | |
|---|---|
| References | Fedorov, O., et al. 2011. Chem. Biol. 18, 67. |
| Product Information | |
|---|---|
| Form | White solid |
| Hill Formula | C₁₅H₁₃Cl₂N₃O₂ |
| Chemical formula | C₁₅H₁₃Cl₂N₃O₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 219511 | 0 |