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219393 Cathepsin S Inhibitor - Calbiochem

Cathepsin S Inhibitor is a slow, tight-binding reversible inhibitor of cathepsin S (Ki = 185 pM). Exhibits 410-fold greater selectivity over cathepsin B (Ki = 76 nM).

Cathepsin S Inhibitor - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Z-FL-COCHO

Primary Target: cathepsin S
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₂₄H₂₈N₂O₅
      Description
      Overview

      This product has been discontinued.



      A slow, tight-binding reversible inhibitor of recombinant cathepsin S (Ki = 185 pM). Exhibits about 410-fold greater selectivity for cathepsin S compared to cathepsin B (Ki = 76 nM).
      Catalogue Number219393
      Brand Family Calbiochem®
      SynonymsZ-FL-COCHO
      References
      ReferencesWalker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.
      Product Information
      ATP CompetitiveN
      Formpale yellow solid
      Hill FormulaC₂₄H₂₈N₂O₅
      Chemical formulaC₂₄H₂₈N₂O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCathepsin S Inhibitor is a slow, tight-binding reversible inhibitor of cathepsin S (Ki = 185 pM). Exhibits 410-fold greater selectivity over cathepsin B (Ki = 76 nM).
      Biological Information
      Primary Targetcathepsin S
      Primary Target K<sub>i</sub>185 pM against cathepsin S
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceZ-Phe-Leu-COCHO • H₂O
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      219393 0

      Documentation

      Cathepsin S Inhibitor - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Cathepsin S Inhibitor - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      219393

      Références bibliographiques

      Aperçu de la référence bibliographique
      Walker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-November-2009 RFH
      SynonymsZ-FL-COCHO
      DescriptionA dipeptidyl α-keto-β-aldehyde that acts as a slow, tight-binding, highly potent, reversible inhibitor of cathepsin S. Exhibits over 410-fold greater selectivity for cathepsin S (Ki = 185 pM) over cathepsin B (Ki = 76 nM).
      Formpale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₈N₂O₅
      Peptide SequenceZ-Phe-Leu-COCHO • H₂O
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWalker, B., et al. 2000. Biochem. Biophys. Res. Commun. 275, 401.