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208725 Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem

A cell permeable, highly specific inhibitor of protein kinase C (IC₅₀ = 50 nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: UCN-1028c

Primary Target: PKC
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      121263-19-2C₄₄H₃₈O₁₄
      Description
      Overview

      This product has been discontinued.



      A cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
      Catalogue Number208725
      Brand Family Calbiochem®
      SynonymsUCN-1028c
      References
      ReferencesJarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
      Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
      Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
      Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
      Tamaoki, T., et al. 1990. Biotechnology 8, 732.
      Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.
      Product Information
      CAS number121263-19-2
      ATP CompetitiveN
      FormLight brown lyophilized solid
      Hill FormulaC₄₄H₃₈O₁₄
      Chemical formulaC₄₄H₃₈O₁₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKC
      Primary Target IC<sub>50</sub>50 nM against protein kinase C
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      208725 0

      Documentation

      Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      208725

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
      Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
      Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
      Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
      Tamaoki, T., et al. 1990. Biotechnology 8, 732.
      Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure

      Citations

      Titre
    • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
    • Yi Dai, et al. (2004) Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. Journal of Neuroscience 24, 4293-4299.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-May-2008 RFH
      SynonymsUCN-1028c
      DescriptionCell-permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src protein tyrosine kinase (IC50 > 50 µM). Does not compete with Ca2+ or phospholipids. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Inhibition of PKC is dependent on exposure to light in cell-free systems. Ordinary fluorescent light is sufficient for full activation.
      FormLight brown lyophilized solid
      CAS number121263-19-2
      Chemical formulaC₄₄H₃₈O₁₄
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (1 mg/ml) or Ethanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesJarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
      Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
      Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
      Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
      Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
      Tamaoki, T., et al. 1990. Biotechnology 8, 732.
      Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.
      Citation
    • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
    • Yi Dai, et al. (2004) Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. Journal of Neuroscience 24, 4293-4299.
      		•