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236013 COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472

Primary Target: COX-2
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      1177728-24-3C₂₀H₂₁Cl₂N₃OS
      Description
      Overview

      This product has been discontinued.



      A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).
      Catalogue Number236013
      Brand Family Calbiochem®
      SynonymsN-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472
      References
      ReferencesMichaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.
      Product Information
      CAS number1177728-24-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₀H₂₁Cl₂N₃OS
      Chemical formulaC₂₀H₂₁Cl₂N₃OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCOX-2
      Primary Target IC<sub>50</sub>at 10.0 µM, % inhibition of COX-1 and COX-2 = 5.1 and 26.36
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      236013 0

      Documentation

      COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      236013

      Références bibliographiques

      Aperçu de la référence bibliographique
      Michaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-April-2011 RFH
      SynonymsN-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472
      DescriptionA thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1177728-24-3
      Chemical formulaC₂₀H₂₁Cl₂N₃OS
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml) or Ethanol (0.5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMichaux, C., et al. 2006. Eur. J. Med. Chem. 41, 1446.